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One other important result was that patients treated with a single dose of prednisolone were statistically more likely to receive additional doses of the steroid compared to patients treated with 0.1 mg (P<0.001), 0.02 mg (P<0.001), and 0.05 mg (P<0.001). Trial Registration clinicaltrials.gov Identifier: NCT01251216 "Although these findings are promising, further studies examining efficacy and the mechanisms of action are needed to determine whether this is the first step in a novel strategy to treat severe acne and other inflammatory skin conditions," study author and dermatologist, Dr. Andrew A. Rizvi of McGill University, Montreal, Quebec, Canada, said in a statement. "Our next step will be to investigate our initial results using larger, randomized controlled trials. We would need to have significant evidence to show that any therapy works, and we would have to be able to show that it's safe." Dr. Arieh A. Siegel, chair of the dermatology department at UCLA, noted that the findings do not necessarily mean that prednisone is a cure-all. It could be that the treatment's effect on inflammation increases with repeated treatments, he said. "It's important to also see the effects of other medications in the treatment regimen, and we've seen that corticosteroids can be helpful." Related Article: